FIGURE

Figure 4

ID

ZDB-FIG-210130-37

Publication

da Silva et al., 2020 - NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss

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Figure 4

Abnormal mineralisation of amorphous material within the adult inner ears and higher BMD in ncoa3−/−. A) 3D renders from μCT images of wt and ncoa3−/− of same age (1 year old). The head was color-coded to show bone mineral density (g.cm³HA; min = 0.338; max = 1.124). Note that craniofacial bones in ncoa3 mutants have higher density compared to wt. Otoliths (otl = arrows) were zoomed in. Abnormal mineralisation (dashed arrows) is observed attached to the otoliths. A cross section picture was taken to show the mineralised amorphous material (arrows) juxtaposed to the otoliths. B) Volume of otoliths. C) Bone mineral density of central region of otoliths. Non-parametric, two-tailed, independent Student’s t-Test was used as statistical analysis (p < 0.05). Scale bars = 500 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ncoa3^{bsl456/bsl456}; hu5910Tg; um14Tg
Observed In:	cranium bone mineralization lagena bone mineralization lapillus otolith regulation of bone mineralization sagitta
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.