FIGURE

Figure 12

ID

ZDB-FIG-201229-88

Publication

Candiani et al., 2020 - Alexander Disease Modeling in Zebrafish: An In Vivo System Suitable to Perform Drug Screening

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Figure 12

Electron micrographs of the telencephalon of 3 dpf zebrafish embryos expressing GFAP R239C-GFP.(A) The formation of lysosomes (arrows) was confirmed in the electron micrographs of the telencephalic region from a 3 dpf old zebrafish, injected with GFAP R239C-GFP plasmid and treated with 1.0 mM ceftriaxone for 48 h. (B) In contrast, in mutant untreated embryos, fewer and smaller lysosomes were seen at this embryonic stage. Images were captured with Zeiss EM10 or a LEO 912AB transmission electron microscope. Scale bar: 2.5 µm.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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