FIGURE

Figure 6

ID

ZDB-FIG-201208-18

Publication

Eufrásio et al., 2020 - In vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes Associated SNPs

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Figure 6

A: Schematic representation of the three different analyzed versions of seq132: seq132wt, seq132risk, and seq132risk#. The gene SLC30A08 is represented in blue. The symbol # represents common variants with no association with type 2 diabetes. The wt and risk alleles are represented in black boxes. B: Representative confocal images for the seq132risk#, showing GFP expression in the endocrine pancreatic domain (dashed line) defined by the sst:mCherry reporter line. The 48-hpf embryos were stained with DAPI. Scale bars = 10 μm. C: Graph representing the total percentages of positive embryos for the seq132wt (23%, n = 34), seq132risk (56%, n = 36), and seq132risk# (20%, n = 20). *P < 0.05, by χ² test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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