FIGURE

Figure 2

ID

ZDB-FIG-201003-251

Publication

Wisniewski et al., 2020 - P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis

Other Figures

All Figure Page

Back to All Figure Page

Figure 2

P130Cas is required for caudal vein plexus (CVP) angiogenesis. (A,B) Maximum intensity projections of wildtype and bcar1^u7000 embryos at 30hpf (A) and 48hpf (B), with inset (blue/orange dashed boxes) showing the sprouting front. Insets are inverted for easier visualisation. Blue line indicates ventral extension, magenta circles endothelial cell gaps, orange arrowheads filopodia-like cell protrusions. (C,D) Quantification of total CVP area, maximal ventral extension, and total non-vascularised area (= ‘EC gaps’) show a significant reduction at both time points. All results displayed as box plots with centre line showing median and box dimensions indicating 25th and 75th quartile. Each data point represents an individual embryo, experimental n from ≥ 3 independent clutches, p values as shown. White boxes are WT, light grey boxes indicate bcar1^u7000. Scale bars as indicated.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bcar1^u7000/u7000; um13Tg; y7Tg bcar1^u7000/u7000; y1Tg
Observed In:	caudal vein plexus caudal vein plexus angiogenesis
Stage Range:	Prim-15 to Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.