FIGURE

Figure 4

ID

ZDB-FIG-200827-4

Publication

Louphrasitthiphol et al., 2020 - Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

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Figure 4

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Figure 4

K243 Controls MITF Function In Vivo

(A) Complementation of neural crest MITFa-null nacre zebrafish using MITF WT and K238 (equivalent to K243 in human MITF) mutants (left) and quantification of numbers of melanocytes (right). The dots in the plots represent numbers of melanocytes in each rescued embryo with at least one melanocyte. See also Figure S3.

(B) Western blot of 501mel cells stably expressing HA-MITF WT and mutants (from the same gel).

(D) Example tumors.

(E) Tumor size over time using indicated cell lines. Error bars indicate S.E.M.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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