ZFIN ID: ZDB-FIG-200727-14
Sinagoga et al., 2020 - Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure. Development (Cambridge, England)   147(21) Full text @ Development
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Long-pec to Day 4

Fig. 1

Zebrafish mitfa;tfec mutants phenocopy human colobomas. (A) At 4 dpf, mitfa−/−;tfec−/− mutants possess colobomas (outlined in red), with a range of severity (B). (C) At 48 hpf, serial sections through the distal (D) to proximal (P) axis of the CF reveal persistent expression of laminin in the mitfa−/−;tfec−/− mutant CF. The boxes indicate the areas enlarged in the insets showing laminin staining within the CF. Dorsal is upwards in all images. Scale bars: 50 µm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mitfaw2/w2 standard conditions Long-pec optic fissure basement membrane absent, normal
Day 4 optic fissure closed, normal
mitfaw2/w2; tfecvc60/+ standard conditions Day 4 optic fissure closed, normal
mitfaw2/w2; tfecvc60/vc60 standard conditions Long-pec optic fissure basement membrane increased amount, abnormal
mitfaw2/w2; tfecvc60/vc60 standard conditions Day 4 optic fissure open, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development