FIGURE

Fig. 7.

ID

ZDB-FIG-200703-7

Publication

Anderson et al., 2020 - Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency

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Fig. 7.

New zebrafish models for CDP. (A-D) Abnormal ossification, marked with arrows, within endochondral growth plates of kol^nu7 (B), kol^nu7/+:msmol^nu81/+ (C) and Tg(fabp10a:msmo1:pA)^nu100;msmo1^nu81 (D) mutant phenotypes resembles defects observed in patients with chondrodysplasia punctata. Images represent lateral views of palatoquadrate growth plates of craniofacial bones from disarticulated whole-mount adult skeletal preparations at ∼4 months of age. Scale bars: 100 μm. Tg*, Tg(fabp10:msmo1:pA)^nu100. wt n=4, kol^nu7 n=6, kol^nu7/+:msmol^nu81/+ n=4, Tg(fabp10a:msmo1:pA)^nu100;msmo1^nu81 n=4.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	msmo1^nu7/nu7 msmo1^nu81/+; msmo1^nu7/+ msmo1^nu81/nu81; nu100Tg
Observed In:	palatoquadrate arch endochondral element palatoquadrate arch ossification
Stage:	Adult

Phenotype Detail

Acknowledgments

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