FIGURE

Figure 4

ID

ZDB-FIG-200627-34

Publication

Linnerz et al., 2020 - The Diverse Roles of Phagocytes During Bacterial and Fungal Infections and Sterile Inflammation: Lessons From Zebrafish

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Figure 4

Schematic illustration of the signaling pathways and mechanisms that help control phagocyte migration and abundance during larval zebrafish acute tail fin injury. (A) A gradient of H₂O₂, generated at the wound margin, is sensed by neutrophils through oxidation of Lyn, leading to directed neutrophil migration (1). Neutrophil-delivered Mpx consumes H₂O₂ producing hypochlorous acid (HOCl) (2). (B) Macrophage arrival at the wound site is promoted by NADPH oxidase activity and Yrk, in addition to Cxcr3.2/Cxcl11(1). In this context, Cxcr3.3 acts as a scavenger receptor to negatively regulate Cxcr3.2 function. Macrophage-delivered PGE2 promotes neutrophil retrograde chemotaxis (2) together with NADPH/Yrk-dependent contact-mediated guidance from macrophages (3). Cxcr2 signaling also contributes to initiate neutrophil retrograde chemotaxis (4). (C) Cxcr4/Cxcl12 signaling contributes to the retention of neutrophils at the wound site (1) along with Hif-1 activation (2). Macrophages at the wound site also remove apoptotic neutrophil debris (3).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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