FIGURE

Figure 1

ID

ZDB-FIG-200619-5

Publication

Cao et al., 2020 - Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin

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Figure 1

Shikonin inhibited melanoma tumor growth in zebrafish xenograft model. Fluorescently labeled (A) A375 or (B) A2058 cells were microinjected into the yolk sac of 2 dpf zebrafish embryos. These zebrafish were then transferred randomly to 24-well plates, 10 embryos per well with 0.5 ml of embryo medium containing indicated concentrations of shikonin or sorafenib for a treatment period of 48 h. Representative images of embryos were shown as merged bright-field and fluorescent images at 0, 24, and 48 h. Relative fluorescence intensity were analyzed by Image J software. Data were shown as mean ± SD from three independent experiments, **P < 0.01. Blue arrows indicated pericardia. (C) H&E staining of A375 cell transplanted zebrafish. Tumor cells in yolk were shown (yellow squares).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg
Condition:	cancer xenotransplantation, chemical treatment by environment: Shikonin
Observed In:	whole organism melanoma
Stage:	Day 4

Phenotype Detail

Acknowledgments

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