FIGURE

Fig. 8

ID

ZDB-FIG-200518-41

Publication

Lu et al., 2020 - Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine

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Fig. 8

smo-mutant embryos, lacking slow-twitch fibres, are unresponsive to Urp over expression. (A) An smo-mutant embryo at 48?hpf. (B) An smo-mutant embryo injected with myog::urp2 transgene. Note that there was no effect on the ventrally curved axis. This experiment was performed in two independent biological replicates. In the first batch, five wild-type siblings showed no dorsal curvature and 57 showed dorsal curvature. All 12 smo mutants showed no response. In the second batch, of 105 wild-type siblings all showed dorsal curvature. All 24 smo mutants showed no response. (C) An smo-mutant embryo at 48?hpf, injected with water in the dorsal somite, imaged after 1?h. (D) An smo-mutant embryo, injected with Urp1 in the dorsal somite, imaged after 1?h. Note that there was no effect on the ventrally curved axis. The injection sites are indicated (magenta arrows). Four embryos were injected for each condition. Scale bars: 1?mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smo^{hi1640Tg/hi1640Tg}
Observed In:	trunk
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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