FIGURE

Figure 2

ID

ZDB-FIG-200513-2

Publication

Griffin et al., 2020 - Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model

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Figure 2

Behavioral screening of 20 compounds which were identified as positive from the library screens. (A) Heat map representing the change of mean swim velocity of the 20 hit compounds. The 20 SCs which were identified from the blind screens were retested at 1, 10, and 100 µM to confirm a dose response effect. Each box represents the percent change in mean velocity from a locomotion assay on at least 6 scn1lab larvae. Compounds marked with a cross were identified as toxic; threshold for positive hits shown by solid line. Scale at right represents the range of % change in mean velocity values. (B) Representative swim behavior traces obtained during a 10 min recording epoch for the top two compounds, #9001523 and #147666.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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