FIGURE

Figure 5

ID

ZDB-FIG-200511-21

Publication

Wen et al., 2020 - Knockdown of Matrix Metallopeptidase 9 Inhibits Metastasis of Oral Squamous Cell Carcinoma Cells in a Zebrafish Xenograft Model

Other Figures

All Figure Page

Back to All Figure Page

Figure 5

Knockdown of MMP-9 decreased the metastatic distance and number of CAL-27 cells in the zebrafish xenograft model. A red fluorescent cluster indicated a tumor mass, and the foci marked by white arrows indicated the metastatic tumor cells or lesions that have escaped from the yolk sac. (a, b) The bright-field and fluorescent pictures of whole-body, head, distal tail regions of zebrafish injected with CAL-27/LVRU6MP and CAL-27/MMP-9/shRNA cells at 3 dpi (n = 120; magnification, ×32, ×63). (c, e) Knockdown of MMP-9 reduced the invasive average distance, maximal distance, and number of disseminated cells or lesions at 3 dpi. ^∗P < 0.05 and ^∗∗P < 0.01 as compared with the control. Bar = 0.5 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU
Condition:	cancer xenotransplantation
Observed In:	whole organism squamous cell carcinoma
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biomed Res. Int.