FIGURE

Fig. 7

ID

ZDB-FIG-200326-50

Publication

Jurynec et al., 2019 - The Paf1 Complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors

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Fig. 7

Loss of Cdk9 function expands both the premigratory and migratory NC populations, and suppresses loss of melanophore formation in aln/paf1 mutants. (A-D) Lateral views of 48 hpf wild-type (A), alnz24 mutant (B), cdk9z26 mutant (C) or alnz24; cdk9z26 double mutant embryos (D). (E-H) NC expression of crestin (E,F) and sox10 (G,H) in 26 hpf wild-type and cdk9z26 mutant embryos. Arrow in C indicates an increase in the number of melanophores in the head of cdk9z26 mutant embryos. Insets in E and F are cross-sections through the trunk of crestin-expressing embryos. Arrows indicate migrating NC and arrowheads indicate premigratory NC.

Expression Data

Genes:	crestin sox10
Fish:	WT nrg1^z26/z26
Anatomical Term:	neural crest
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nrg1^z26/z26 paf1^z24/z24 nrg1^z26/z26; paf1^z24/z24
Observed In:	melanocyte neural crest
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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