Figure 2

Schematic representation of human Ca_V2.1 mutations causing familial hemiplegic migraine type 1 (FHM1). Please note that residue numbering varies between studies due to the existence of multiple CACNA1A splice variants; residue numbers indicated reflect those stated in the original report. Citations to the indicated mutations are listed as follows: R192Q—Ophoff et al. (1996); R195K—Ducros et al. (2001); S218L—Kors et al. (2001); P225H—Stuart et al. (2012); G230V—Yang et al. (2014); F363S—Riant et al. (2010); V581M—Cuenca-León et al. (2008); V581L—Freilinger et al. (2011); R583Q—Battistini et al. (1999); T666M—Ophoff et al. (1996); V714A—Ophoff et al. (1996); D715E—Ducros et al. (2001); E1015K—Grieco et al. (2018); Y1245C—Cuenca-León et al. (2008); K1336E—Ducros et al. (2001); R1347Q—Alonso et al. (2004); C1370Y—Thomsen et al. (2007); Y1385C—Vahedi et al. (2000); V1457L—Carrera et al. (1999); F1506S—Riant et al. (2010); F1506Y—Pelzer et al. (2018); I1512T—Grieco et al. (2018); C1535S—Dichgans et al. (2005); F1609L—Pelzer et al. (2018); R1668W—Ducros et al. (2001); K1670R—Riant et al. (2010); L1682P—Weiss et al. (2007); W1684R—Ducros et al. (2001); V1696I—Ducros et al. (2001); I1710T—Kors et al. (2004); D1725N—Riant et al. (2010); I1811L—Ophoff et al. (1996); A2006T—Wilson (2014); R2157G—Grieco et al. (2018). The Ca_V2.1 schematic was modified from Tyagi et al. (2019) with permission of the authors.