FIGURE

Figure 3

ID

ZDB-FIG-200302-42

Publication

Wang et al., 2020 - Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment

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Figure 3

CYM-5478 attenuates cisplatin-mediated degeneration of zebrafish hair cells. (A) CYM-5478-mediated activation of the zebrafish homolog of S1P₂ (zS1P₂) was evaluated by the receptor-specific TGFα-shedding assay. Human S1P₂ (hS1P₂) was used as a reference. (B) Representative images of zebrafish larvae treated with cisplatin in the presence of NAC (1 mM) or CYM-5478 (20 μM). Viable neuromasts were labeled with YO-PRO-1. (C) Quantification of YO-PRO-1-positive neuromasts. (*** p < 0.001, n = 4).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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