FIGURE

Figure 1

ID

ZDB-FIG-200125-46

Publication

Uechi et al., 2019 - Zebrafish Models of Diamond-Blackfan Anemia: A Tool for Understanding the Disease Pathogenesis and Drug Discovery

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Figure 1

Zebrafish DBA models. Wild-type embryos show a high density of red blood cells (WT), whereas the blood production is drastically reduced in the rps19 knockdown (KD) and knockout (KO) embryos, as indicated by the absence of hemoglobin stained cells (lower panels). These embryos also display developmental deformities in head and tail regions (arrowheads). The abnormal phenotypes were rescued by injection of rps19 mRNA but not rescued by mRNA with patient type mutations in the knockdown embryos [14].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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