FIGURE

Figure 2

ID

ZDB-FIG-200125-13

Publication

Chen et al., 2020 - Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model

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Figure 2

Effects of berberine (BBR) on hepatic steatosis in high-cholesterol diet (HCD)-induced zebrafish larvae. (A) The zebrafish larvae were treated with the control diet, HCD diet, and HCD plus BBR (5 μM) treatment. Hepatic steatosis was observed by whole-body Oil Red O (ORO) staining (line 1, refer to the black dotted, bar = 100 μm), H&E staining (line 2, refer to the yellow dotted, bar = 100 μm), and TEM (line 3, bar = 2μm; line 4, bar = 1 μm). m mitochondrion, n cell nucleus, LD lipid droplet. (B) L-plastin-labeled macrophages in Tg (fabp10a: dsRed) zebrafish. The statistical results of the positive area of ORO staining were shown in (C) and the quantity of macrophage in the liver of larval zebrafish in (D). Effects of BBR on the levels of triglyceride (E), glucose (F), and cholesterol (G) in livers of zebrafish larvae fed with HCD. ^#Compared with the HCD group, P < 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB gz15aTg
Conditions:	high cholesterol chemical treatment by environment: berberine, high cholesterol
Observed In:	liver liver cholesterol liver glucose liver macrophage liver triglyceride
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

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