FIGURE

Figure 6

ID

ZDB-FIG-200113-8

Publication

Kim et al., 2019 - Thiostrepton: A Novel Therapeutic Drug Candidate for Mycobacterium abscessus Infection

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Figure 6

Evaluation of in vivo TST activity on Mab CIP 104536 R morphotype expressing mWasabi infection. (A) Mab expressing mWasabi (≈400 CFU) was infected via caudal vein infection and visualized in untreated or drug-treated embryos. (B) Bacterial loads of untreated, TST, and CLA treated embryos. Results are expressed as mean log₁₀ CFU per embryo from three independent experiments. Significant difference (*** P < 0.0001) compared with untreated control. Survival of Mab- infected embryos treated at 1 and 5 μM of TST (C) and CLA (D) in comparison with untreated infected embryos and non-treated control (n = 20, representative of three independent experiments). Survival curves were compared with Log-rank (Mantel-Cox) test (* P < 0.05; ** P < 0.01; *** P < 0.001; ns, not significant). TST, thiostrepton; CLA, clarithromycin.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	bacterial treatment by injection: Mycobacteroides abscessus bacterial treatment by injection: Mycobacteroides abscessus, chemical treatment by environment: thiostrepton
Observed In:	whole organism
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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