FIGURE

Fig. 4

ID

ZDB-FIG-191230-719

Publication

Giallongo et al., 2019 - TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma

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Fig. 4

MM-MSC and SMM-MSC enhanced PC engraftment and promoted immune escape mechanisms in zebrafish.

Three animals were engrafted for every combination of PC with SMM-MSC (n = 3), MM-MSC (n = 8) or HC-MSC (n = 4). a Evaluation of tumor xenografts was performed by tomography after 6 days. b Detection of human MM cells using flow cytometry. c Analysis of changes in the Th1/Th2 balance in zebrafish using real time PCR. Results for animals co-injected with PC and MM-MSC are shown (compared to animals injected with PC and HC-MSC); calculated value of 2^−ΔΔCt in zebrafish injected with U266 and HC-MSC was 1. All analyses were performed 6 days after cellular mixture injection. *p < 0.05; **p < 0.01; ***p < 0.001

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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