FIGURE

FIG 5

ID

ZDB-FIG-191230-178

Publication

Burggraaf et al., 2019 - Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease

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FIG 5

Deletion of PecA causes attenuation of virulence in an in vivo zebrafish infection model. (A) A total of 273 zebrafish larvae were infected 1 day postfertilization (dpf) with wild-type (75 larvae), ΔpecA (71 larvae), ΔpecA plus pecA_myc (62 larvae), or ΔpecA plus ΔpecA_D293Gmyc (65 larvae) M. marinum M strains (see Table S2 for input CFU). Graph shows relative infection from 4 independent experiments as calculated by normalized integrated fluorescent intensity per larva at 4 days postinfection, with mean intensity and standard deviation for the entire population. Similar effects were obtained for CFU counts at 4 dpi with wild-type, ΔpecA, and ΔpecA plus pecA_myc strains (Fig. S6). (B) Representative images of infected larvae are shown for each strain.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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