Figure 6—figure supplement 2.

(A) Summary of results from paper. In a social environment, EDN from the vasculature increases myelin sheath number in the medial prefrontal cortex, influencing sociability. In social isolation vascular EDN production is reduced, leading to a decreased number of myelin sheaths formed by oligodendrocytes and reduced sociability. Oligodendroglial knock out of EDNRB reduces the number of myelin sheaths formed by oligodendrocytes and reduced sociability. (B) Proposed hypothesis for how EDN signalling links neuronal activity to increased myelination and thus support of active axons. 1. Increased local neuronal activity signals to the vasculature to increase blood flow to the active area 2. The increased blood flow stimulates EDN production from endothelial cells 3. Increased EDN levels leads to the formation of more myelin sheaths by oligodendrocytes. Figures created with Biorender.