FIGURE
Figure 5
- ID
- ZDB-FIG-191230-1478
- Publication
- Duchemin et al., 2019 - Mechanically activated Piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis
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Figure 5
Hippo pathway effector Yap1 is active and Yap1 is essential for valve formation in the OFT. (A) Confocal z-sections of the double transgenic line 4xGTIIC:d2GFP; kdrl:membrane-mCherry counterstained with the Elnb antibody and focused on the OFT. Scale bar: 20 µm. (B) Example of the valve phenotypes (normal, thick, delayed and no valve) and quantification of the phenotypes in the yap1+/+ controls embryos, yap1+/- and in yap1-/- mutant embryos. Chi-square test. n.s.: non significant, ***: p<10−3. Scale bar: 10 µm. Results obtained from two independent experiments. |
Expression Data
| Genes: | |
|---|---|
| Antibody: | |
| Fish: | |
| Anatomical Terms: | |
| Stage: | Protruding-mouth |
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Observed In: | |
| Stage Range: | Protruding-mouth to Day 5 |
Phenotype Detail
Acknowledgments
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