FIGURE

Figure 5

ID

ZDB-FIG-191230-1478

Publication

Duchemin et al., 2019 - Mechanically activated Piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

Other Figures

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Figure 5

Hippo pathway effector Yap1 is active and Yap1 is essential for valve formation in the OFT. (A) Confocal z-sections of the double transgenic line 4xGTIIC:d2GFP; kdrl:membrane-mCherry counterstained with the Elnb antibody and focused on the OFT. Scale bar: 20 µm. (B) Example of the valve phenotypes (normal, thick, delayed and no valve) and quantification of the phenotypes in the yap1+/+ controls embryos, yap1+/- and in yap1-/- mutant embryos. Chi-square test. n.s.: non significant, ***: p<10−3. Scale bar: 10 µm. Results obtained from two independent experiments.

Expression Data

Genes:	d2EGFP mCherry
Antibody:	Ab1-elnb
Fish:	mw50Tg; y171Tg
Anatomical Terms:	bulbus arteriosus vascular endothelium bulbus arteriosus vascular smooth muscle
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	yap1^fu48/fu48 yap1^fu48/+
Observed In:	ventriculo bulbo valve ventriculo bulbo valve morphogenesis
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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