FIGURE

Fig. 5

ID

ZDB-FIG-191122-8

Publication

Sufian et al., 2019 - CB₁ and CB₂ receptors play differential roles in early zebrafish locomotor development

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Fig. 5

Effect of the endocannabinoid receptor antagonists, AM251 and AM630 on morphological development in 5 dpf zebrafish larva. (A) Incidence of pericardial edema and yolk sac edema in 5 dpf larvae when treated with AM251 and AM630 in the first and second 24?h of development. Scale bars: 0.7?mm. (B,D) Rates of pericardial and yolk sac edema and tail and body malformation in 5 dpf larvae treated with AM251 and AM630 in the first 24?h of development (n=62, 56, 51 and 58 for vehicle control, 0.5?�mol l^?1 AM251, 5?�mol l^?1 AM630 and 0.5?�mol l^?1 AM251+5?�mol l^?1AM630, respectively). (C,E) Rates of pericardial and yolk sac edema and tail and body malformation in 5 dpf larvae treated with AM251 and AM630 in the second 24?h of development (24?48?hpf) (n=74, 56, 62 and 64 for vehicle control, 0.5?�mol l^?1 AM251, 5?�mol l^?1 AM630 and 0.5?�mol l^?1 AM251+5?�mol l^?1 AM630, respectively). Data are presented as means�s.e.m. ^aSignificantly different from vehicle control, P<0.05; ^bsignificantly different from 0.5?�mol l^?1AM251, P<0.05; ^csignificantly different from 5?�mol l^?1 AM630, P<0.05 (one-way ANOVA followed by Tukey?s post hoc multiple comparisons test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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