FIGURE

Fig. 5

ID

ZDB-FIG-190913-1

Publication

Schaeffer et al., 2019 - Autosomal Dominant Tubulointerstitial Kidney Disease with Adult Onset due to a Novel Renin Mutation Mapping in the Mature Protein

Other Figures

Fig. 5

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Fig. 5

Expression of L381P renin variant induces alteration in the pronephros of zebrafish embryos. The pronephros of 5 dpf zebrafish embryos is labelled by reporter transgene EGFP (line ia20Tg¹⁷). (a–c) Embryos injected with wild type (WT), L381P and L16del renin mRNAs show three different phenotypes: normal convoluted pronephric tubules; tubules with reduced convolutions (mild phenotype); absence of tubular convolution (severe phenotype). (d) Histograms showing the percentage of embryos with normal pronephros, or mild or severe pronephric alterations. Samples injected with renin mutants L381P (n = 112) and L16del (n = 122) show significantly increased frequency of altered pronephric tubules relative to wild type (n = 183) (chi-square analysis).

Expression Data

Gene:	EGFP
Fish:	ia20Tg
Anatomical Term:	pronephros
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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