FIGURE

Fig. 5

ID

ZDB-FIG-190820-10

Publication

Fontenas et al., 2019 - The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

A2a AR Inhibition Reduces Neural Activity of Spinal Cord Neurons

(A) Lateral views of a 60 hpf WT olig2:dsred;sox10:eos larva stained with an A2a AR antibody. Top: spinal cord (CNS) with A2a expression in a subset of olig2⁺ motor neurons (asterisks). Bottom (PNS): peripheral spinal nerves with A2a expression in motor (closed arrowheads) and sensory (open arrowheads) axons.

(B) adora2ab mRNA expression at 72 hpf in the spinal cord of a WT larva. Yellow asterisks denote motor neurons.

(C) Twenty-five hours post-fertilization olig2:egfp embryo labeled with SCH-red fluorescent antagonist. Arrowheads mark spinal cord olig2⁺/SCH-red⁺ motor neurons.

(D) Mean ± SEM of the fold change in ΔF/F₀ over time per individual firing event for larvae treated with DMSO (n = 8 neurons from eight larvae) and SCH-58261 (n = 11 neurons from ten larvae); p = 0.01. Scale bars, 20 μM.

Expression Data

Genes:	adora2ab DsRed2 Eos
Antibody:	Ab2-adora2a
Fish:	AB vu19Tg; w9Tg
Anatomical Terms:	motor neuron axon oligodendrocyte peripheral neuron axon spinal cord spinal cord motor neuron
Stage Range:	Pec-fin to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.