FIGURE

Fig. 11

ID

ZDB-FIG-190819-9

Publication

Su et al., 2019 - A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish

Other Figures

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Fig. 11

Immunoreactive score of phospho- mammalian target of the rapamycin (mTOR) (at Ser2448, inactive form) immunostaining for the AKT/mTOR pathway reveals that the expression of mTOR has no significant difference between control and AURKA transgenic fish. (A) Representative images of p-mTOR staining for PTEN in control, AURKA(WT), and AURKA(V352I) at 3, 5, 7, 9, and 11 months; (B) Selected enlarged images show the p-mTOR signals from AURKA(WT)—11 M and AURKA(V352I)—11 M; (C) Statistical analysis of p-mTOR immunostaining IRS score at 3, 5, 7, 9, and 11 months. IRS score of control fish (Tg(fabp10a:EGFP-mCherry) abbreviated as mC, AURKA(WT) and AURKA(V352I) is shown in red (3 M), orange (5 M), green (7 M), purple (9 M), and blue (11 M). Statistical analysis of results was performed using a two-tailed Student’s t-test. The error bar means standard deviation. Asterisks (*) represent the level of significance. * p-value ≤ 0.05.

Expression Data

Antibody:	Ab8-mtor
Fish:	nn1000Tg nn1010Tg nn1011Tg
Anatomical Term:	liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nn1010Tg
Observed In:	liver
Stage:	Adult

Phenotype Detail

Acknowledgments

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