FIGURE

FIGURE 3

ID

ZDB-FIG-190723-80

Publication

Mercurio et al., 2019 - Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos

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FIGURE 3

Quantification of the anti-angiogenic effects in zebrafish embryos. Stalks length (A) and number (B) were measured for fli1a:EGFP zebrafish embryos at 75hpf treated with vehicle, Thalidomide or compounds at different concentrations. The box and whiskers plots show the data points quantified for at least ten embryos per condition. (C) Representative confocal images of zebrafish for each condition. White arrows show a missing stalk, a reduction in vessel length or loss of vascular connectivity. (D) The length of stalks was plotted here for three different groups of stalks. Statistics were calculated by one-way ANOVA. n.s. = not significant; *p < 0.05; ^∗∗p < 0.01; ***p < 0.001; ****p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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