FIGURE

Fig. 8

ID

ZDB-FIG-190723-696

Publication

Yu et al., 2019 - Neddylation Facilitates the Antiviral Response in Zebrafish

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Fig. 8

nedd8-null adult zebrafish are more sensitive to SVCV infection than WT zebrafish. (A,B) nedd8-null zebrafish (3 mpf; 0.38 ± 0.02 g) and the WT (3 mpf; 0.38 ± 0.02 g) were each i.p. injected with 10 μL SVCV (~2 × 10⁸ TCID₅₀/ml) at 0 day. (C,D) At 1 day post-injection (dpi), there were no obvious differences between the WT (nedd8^+/+) and nedd8-null zebrafish (nedd8^−/−). (E,F) At 2 dpi, the WT zebrafish appeared normal, but the nedd8-null zebrafish had more swelling and hemorrhagic symptoms in the abdomen (indicated by red arrows).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nedd8^{ihb1227/ihb1227} (AB)
Condition:	viral treatment by injection: Sprivivirus cyprinus
Observed In:	defense response to virus whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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