FIGURE

Fig. 5

ID

ZDB-FIG-190723-2549

Publication

Martorano et al., 2019 - The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria

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Fig. 5

Investigation of dNTP metabolism in zebrafish larvae. (A) Visualization of iridophores in the tail region of 3?dpf larvae treated with different mixtures of dNTPs. (B) Relative quantification of iridophore number (n=27). (C) Wild-type embryos were treated with dimethyl sulfoxide and 2?μM leflunomide, inhibitor of pyrimidine biosynthesis. Whole-body bright-field pictures (a,b) and birefringent images of the tail region (c,d) are shown. (D) Quantification of relative amounts of iridophores (n=27). Arrowheads point to iridophores. Scale bars: 100?µm. Statistical analyses were performed using two-tailed Student's t-test. Statistical significance was evaluated by setting a confidence interval of 95%; data are mean±s.e.m. ****P<0.0001; ***P<0.001; **P<0.01. Experiments were performed in biological replicates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT mpv17^a9/a9
Conditions:	chemical treatment by environment: dATP chemical treatment by environment: dGTP chemical treatment by environment: dUTP chemical treatment: leflunomide
Observed In:	iridophore post-vent region
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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