FIGURE

Figure 4

ID

ZDB-FIG-190723-2479

Publication

Olson et al., 2018 - Using Zebrafish to Study Collective Cell Migration in Development and Disease

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Figure 4

Signaling and chemotactic pathways active during pLLP migration. (A) Signaling pathways active during pLLP migration. Wnt signaling is active in the leading region (blue and green cells). Wnt signaling initiates expression of Fgf3/10a in the leading cells. Fgf 3/10a activate Fgf signaling in the trailing region (orange). Wnt signaling initiates expression of sef , an inhibitor of Fgf signaling. Fgf signaling initiates expression of dkk1 and dkk2, inhibitors of Wnt signaling. Thus the two signaling regions are maintained through mutual inhibition. (B) Chemokine signaling during pLLP migration. Green strip indicates the internal Cxlc12a generated within the pLLP. cxcr4b chemokine receptor (yellow) is expressed in the leading 2/3 of the pLLP. cxcr7b is expressed in the trailing 1/3 of the pLLP (purple).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol