FIGURE

Figure 1

ID

ZDB-FIG-190723-2443

Publication

Vergunst et al., 2017 - Macrophages as drivers of an opportunistic infection

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Figure 1

FIGURE 1: <italic>B. cenocepacia</italic> requires macrophages for efficient replication and the induction of acute pro-inflammatory disease.

Zebrafish larvae are highly sensitive to infection with B. cenocepacia K56-2. Injection of a small inoculum (5 - 50 colony forming units) causes rapid pro-inflammatory fatal disease that requires the presence of macrophages, but not neutrophils. Macrophages are important for the observed increase in il1b expression. In the absence of macrophages, either using a Pu.1 morpholino knockdown approach or chemical ablation based on the Metronidazole / Nitroreductase system, B. cenocepacia K56-2 is unable to proliferate as in wildtype. This phenomenon was observed when the bacteria were injected intravenously and subcutaneously.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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