FIGURE

Figure 1

ID

ZDB-FIG-190723-2413

Publication

Wafer et al., 2017 - The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) in Adipogenesis: Applying Knowledge from the Fish Aquaculture Industry to Biomedical Research.

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Figure 1

Overview of peroxisome proliferator-activated receptor gamma (PPARG) structure, DNA-binding specificity, and identification of human PPARG genetic variation conserved to fish. (A) Schematic illustrating the domain organization of human PPARG. (B) PPARG:RXRA-binding motifs for human (upper motif) and mouse (lower motif). Motifs are derived from the JASPAR database (http://jaspar.genereg.net/). (C) PPARG domain structure with dbSNPS predicted to be deleterious using SIFT and Polyphen, and conserved to zebrafish, Nile tilapia, and fugu. Red single nucleotide polymorphisms (SNPs) indicate functional verification (9). Yellow–brown histogram indicates the degree of conservation in PPARG between human, mouse, coelacanth, spotted gar, zebrafish, fugu, and Nile tilapia. Height and color indicate the degree of conservation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)