FIGURE

Fig. 1.

ID

ZDB-FIG-190723-2376

Publication

Carneiro et al., 2016 - Telomeres in aging and disease: lessons from zebrafish

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Fig. 1.

Telomeres shorten at different rates, anticipating local and systemic tissue dysfunction in zebrafish aging. Telomeres shorten naturally over time in specific zebrafish organs, such as the gut and muscle (but not testes), regardless of differences in proliferation rates. This shortening, together with the accumulation of local telomere damage, precludes the onset of tissue-dysfunction events in aging, including intestinal inflammation and sarcopenia. Critically short telomeres in the gut and muscle might prove to be sufficient in disrupting homeostasis in unrelated tissues, where telomeres do not shorten, by generating systemic signals (purple) of dysfunction that create a ‘disease-permissive’ environment.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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