FIGURE

Figure 1

ID

ZDB-FIG-190723-2134

Publication

Horsfield et al., 2012 - Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies

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Figure 1

Overview of the cohesin complex and its associated proteins. The cohesin complex consists of four core subunits: SMC1, SMC3, RAD21, and SA. Together these subunits form a large ring capable of topologically encircling DNA strands. Other proteins regulate cohesin’s binding to DNA and its residency there. The NIPBL/MAU2 dimer loads cohesin onto DNA, whereas WAPL/PDS5 release cohesin from chromosomes by opening the SMC3-RAD21 interface.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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