FIGURE

Figure 2

ID

ZDB-FIG-190723-2041

Publication

Allard et al., 2018 - IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

Other Figures

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Figure 2

Different modes of Insulin-like growth factor-binding protein (IGFBP) actions. (A) Inhibition of insulin-like growth factor (IGF) signaling by sequestering IGFs away from the IGF-1 receptor (IGF1R). (B) Promotion of IGF signaling by proteolytic cleavage of the IGFBP and liberation of IGFs from the IGF/IGFBP complex for binding to the IGF1R. (C) Enhancement of IGF signaling by concentrating IGF locally and increasing IGF availability for binding to the IGF1R. (D) IGF-independent actions. Some IGFBPs have been shown to be capable of translocating into the nucleus in certain cells and may affect gene transcription directly or indirectly. Some IGFBPs have been found to bind to cell surface proteins that may act as IGFBP receptors.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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