FIGURE

Fig. 3

ID

ZDB-FIG-190716-28

Publication

Yang et al., 2019 - Network-pharmacology-based identiﬁcation of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis

Other Figures

Fig. 3

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Fig. 3

EEOD suppressed migration and invasion of high-metastatic breast cancer cell lines MDA-MB-231 and MDA-MB-453. (A–B) Wound healing assay demonstrated that EEOD treatment could remarkably decrease the healing area and migration distance of both MDA-MB-231 and MDA-MB-453 cells. The histogram (below) is the quantitative analysis of the healing area and migration distance (up). (40×). (C) Transwell assay indicated that EEOD could decrease the invasive cell number of both MDA-MB-231 and MDA-MB-453 cells. The histogram (right) is the quantitative analysis of the invasive cell number (left). (200×). (D) EEOD treatment (0–50 μg/ml) could dramatically attenuate the expression of multiple metastasis-related proteins in both MDA-MB-231 and MDA-MB-453 cells in a time-concentration dependent manner, including MMP2, MMP9, N-cadherin and vimentin. (E) EEOD at concentrations from 20 μg/ml to 40 μg/ml significantly decreased the number of disseminated tumor foci in the zebrafish body when compared with control group. ^*p ＜ 0.05, ^**p ＜ 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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