FIGURE

Fig. 2

ID

ZDB-FIG-190708-40

Publication

Breuer et al., 2019 - QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis

Other Figures

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Fig. 2

Characterization of Qdprb1.

(A) WISH of qdprb1 at 24 hpf (dorsal view, anterior to the left) shows staining in eye (red arrow) and mid-hindbrain boundary (black arrow), at 48 hpf (lateral view, anterior to the left) in the optic tectum (blue arrow) and the mid-hindbrain boundary (black arrow) and CMZ (inset; red arrow, dorsal view, anterior to the left), and at 72 hpf (dorsal view, anterior to the left) in proliferative regions of the optic tectum (black arrow, left picture), CMZ (red arrow, right picture, dorsal view of the eye), as well as inner retinal layer (black arrow). (B) Lateral views, anterior to the left. Comparison of wildtype embryos at 18 hpf, 24 hpf and 72 hpf and qdprb1 hypomorphic embryos exhibit abnormal midbrain (red arrow) and anterior hindbrain (blue arrow) morphology and microcephaly.

Expression Data

Gene:	qdprb.1
Fish:	AB
Anatomical Terms:	ciliary marginal zone eye midbrain hindbrain boundary optic tectum optic tectum proliferative region retina
Stage Range:	Prim-5 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-qdprb.1
Knockdown Reagent:	MO1-qdprb.1
Observed In:	brain brain development head hindbrain midbrain
Stage Range:	14-19 somites to Protruding-mouth

Phenotype Detail

Acknowledgments

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