Fig. 3
- ID
- ZDB-FIG-190604-29
- Publication
- Jung et al., 2018 - The Ancient Origins of Neural Substrates for Land Walking
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Development of Fin MNs in Danio rerio, Scyliorhinus canicula, and Callorhinchus milii, Related to figure 3 (A) Raldh2 expression is not detected in fin-level MNs of catshark (Scyliorhinus canicula) or elephant shark (Callorhinchus milii). In both species, expression of Raldh2 is detected in the tissue surrounding the spinal cord, similar to the pattern observed in mice. (B) Dorsal view of 48hpf zebrafish embryo showing Foxp1 expression at pectoral (pec) levels. Isl1 staining labels a subset of MNs as well as larger diameter sensory neurons. Foxp1 expression in the ventral spinal cord extends from the hindbrain to the rostral spinal cord, adjacent to myotomes m2-m5, consistent with previous studies (Ma et al., 2010). (C and D) High-magnification images of Foxp1 protein expression at pectoral levels in zebrafish, showing colocalization with Mnx1::GFP (at 72 hpf) and Isl1 (at 48 hpf). In zebrafish a subset of Foxp1+ neurons express Isl1 at relatively weak levels. (E) Whole-mount NFAP staining showing projection of motor axons toward the pectoral and pelvic fin in catshark. (F) Sections of catshark embryos showing a subset of Foxp1+ MNs express Isl1 or Lhx1. In catshark LMCm and LMCl neurons appear to be intermixed. |
Reprinted from Cell, 172, Jung, H., Baek, M., D'Elia, K.P., Boisvert, C., Currie, P.D., Tay, B.H., Venkatesh, B., Brown, S.M., Heguy, A., Schoppik, D., Dasen, J.S., The Ancient Origins of Neural Substrates for Land Walking, 667-682.e15, Copyright (2018) with permission from Elsevier. Full text @ Cell