FIGURE

Fig. 1

ID

ZDB-FIG-190404-13

Publication

Chen et al., 2018 - Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity

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Fig. 1

Among the natural products screened in Tg(fli1a: EGFP)y1 zebrafish, mundoserone was identified as an anti-angiogenic compound. Representative (A-C) bright-field and (D-F) fluorescent images of zebrafish embryos at 24 h post-fertilization treated with 0.1% dimethyl sulfoxide (control), 10 µM mundoserone or 5 µM PTK787 (positive control) for 24 h (magnification, ×40). (G-I) Magnification of images (D-F) (magnification, ×112.5). Compared with those in the control group, embryos treated with mundoserone presented with a lower number of incomplete ISVs and only occasional sprouts (asterisks) of the DA were observed. (J) Chemical structure of mundoserone. DLAV, dorsal longitudinal anastomotic vessels; ISVs, intersegmental vessels; DA, dorsal aorta; PCV, posterior cardinal vein.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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