FIGURE

Fig. 1

ID

ZDB-FIG-190301-12

Publication

Crilly et al., 2018 - Using zebrafish larval models to study brain injury, locomotor and neuroinflammatory outcomes following intracerebral haemorrhage

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Fig. 1

Atorvastatin (ATV)-induced and bubblehead (bbh) mutant intracerebral haemorrhage (ICH) show comparable models of brain-specific bleeding. (A) Brain-specific bleeds were observed in both ATV and bbh models maintained on the transgenic gata1:DsRed reporter background using both brightfield (top panels) and fluorescence (bottom panels) microscopy. Bleeds formed in both forebrain and mid-hindbrain regions, as described by others (Eisa-Beygi et al., 2013) (arrows denotes haemorrhages). Bleeds in bbh mutants are frequently associated with severe cranial oedema making blood pooling more disperse. Original magnification, x20. (B) ATV treatment causes ICH to occur in a dose-dependent manner. (C) Timeline of ICH development in ATV-treated and untreated embryos and (D) bbh homozygotes.

Expression Data

Gene:	DsRed
Fish:	sd2Tg arhgef7b^m292/m292; sd2Tg
Condition:	chemical treatment by environment: atorvastatin
Anatomical Terms:	brain blood forebrain blood midbrain blood
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sd2Tg arhgef7b^m292/m292; sd2Tg
Condition:	chemical treatment by environment: atorvastatin
Observed In:	brain
Stage Range:	Prim-25 to Long-pec

Phenotype Detail

Acknowledgments

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