FIGURE

Fig. 7

ID
ZDB-FIG-190131-8
Publication
Gordon et al., 2018 - Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis
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Fig. 7

Canonical signaling via Gli1 is required for coloboma in the ptch2tc294z mutant. (A) Inhibition of non-canonical Hh signaling via Src-family kinases (SFKs) does not rescue coloboma in the ptch2tc294z mutant. Graph shows percentage of ptch2tc294z mutant embryos with coloboma, normalized to the DMSO control group. (B) Genetic loss of one or both copies of gli1 (using gli1ts269) partially rescues the coloboma phenotype in the ptch2tc294z mutant. Percentage of embryos with coloboma is shown. Numbers in parentheses indicate n. (C-F) Representative images of embryos from the genetic experiments shown in B, 55 hpf. (C) ptch2+/−; gli1any. (D) ptch2−/−; gli1+/+. (E) ptch2−/−; gli1+/−. (F) ptch2−/−; gli1−/−. Arrow indicates coloboma.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Long-pec

Phenotype Detail
Acknowledgments
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