FIGURE

Fig. 7

ID

ZDB-FIG-181120-21

Publication

Fernando et al., 2018 - Diphlorethohydroxycarmalol Isolated from Ishige okamurae Represses High Glucose-Induced Angiogenesis In Vitro and In Vivo.

Other Figures

Fig. 7

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Fig. 7

DPHC inhibited high glucose-induced dilation in hyaloid retinal vessel diameter and the whole body vessel formation in the zebrafish transgenic (flk:EGFP) embryo. A: 0 mM glucose + 0 μM DPHC; B: 130 mM glucose + 0 μM DPHC; C: 130 mM glucose + 0.06 μM DPHC; D: 130 mM glucose + 0.2 μM DPHC; E: 130 mM glucose + 0.6 μM DPHC; F: 130 mM glucose + 2 μM DPHC. (a) Images of hyaloid retinal vessels of the zebrafish transgenic (flk:EGFP) embryo taken with florescence microscopy (10×). (b) Quantification of the hyaloid retinal vessel diameter. (c) Images of the zebrafish transgenic (flk:EGFP) embryo’s whole body taken with florescence microscopy (4×). (d) Quantification of the whole body florescence intensity. The effect of 130 mM of glucose is compared with the blank (130 mM glucose + 0 μM DPHC), ^# p ˂ 0.05. The effect of DPHC against high glucose-induced vessel growth is normalized to the control (130 mM glucose + 0 μM DPHC); ns, not significant, * p ˂ 0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf531Tg
Conditions:	chemical treatment by environment: glucose chemical treatment by environment: algal metabolite
Observed In:	hyaloid vessel whole organism blood vessel development
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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