FIGURE

Fig. 8

ID

ZDB-FIG-181002-11

Publication

Casar et al., 2018 - RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

Oncogenic effects of activated RAS at the GC. a Expression of the indicated constructs transfected (1 μg) in CHL melanocytes. b Kaplan–Meier plot of the Incidence of melanoma by 10 weeks post fertilization in nacre zebrafish expressing the indicated HRASV12 site-specific transgenes using the miniCoopR system. c Representative images of adult zebrafish expressing the indicated HRASV12 site-specific transgenes at 8 weeks post fertilization compared to nacre. Insets are magnification of stripes. d Representative images of zebrafish embryos expressing the indicated HRASV12 site-specific transgenes at 3 days post fertilization compared to uninjected nacre. e Apoptosis induction by the indicated HRASV12 site-specific constructs in CHL melanoma cells. Results, relative to the values found in vector-transfected cells, show average ± SEM from three independent experiments **p < 0.01 by Student's t-test. See also Supplementary Fig. 7

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.