FIGURE

Fig. S7

ID

ZDB-FIG-181001-11

Publication

Moore et al., 2013 - Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube

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Fig. S7

Mutation of the HMG box site within Motif3 reduces CNE1 activity. (A) Schematic outlining the mutations introduced into the HMG box site of Motif3. M3Mut1 transgenic zebrafish exhibit a reduction in CNE1 activity compared to controls (compare B to D) (n = 25/41, p<0.001). A similar reduction in CNE1 activity is observed in M3Mut2 transgenics (compare B to G) (n = 6/32, p<0.001). (F) Graphical summary of the effect of HMG binding site mutations upon CNE1 activity in zebrafish embryos. Experiments performed in chick reveal a reduction in CNE1 activity in both M3Mut1 (n = 3/7) and M3Mut2 (n = 2/5) electroporations, however this result did not reach statistical significance (compare C to E and H, respectively).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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