FIGURE

Fig. S5

ID

ZDB-FIG-180918-8

Publication

Yang et al., 2018 - Central role of autophagic UVRAG in melanogenesis and the suntan response

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Fig. S5

Related to Fig. 3: Effect of UVRAG deficiency on melanosome biogenesis in vivo. (A) Schematic representation of injected vectors containing the morpholino (MO) target sequence fused to GFP. The target site of uvrag, tyr, and pmel is fused to the 5’ of GFP. (B) Efficacy and specificity of uvrag, pmel,, and tyrosinase (tyr) MO. Left panels show Zebrafish embryos injected with the MO target-GFP fusion constructs as indicated. Right panels show co-injection of both MO target-GFP fusion constructs and MOs as indicated. Embryos were imaged at 10 hrs and 30 hrs post-fertilization (hpf) with the exposure time of 1.5 s in all groups. The disappearance of GFP expression (right panels) highlights the specific depletion of the target gene in Zebrafish embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA