FIGURE

Fig. S6

ID

ZDB-FIG-180913-63

Publication

Asakawa et al., 2018 - Protocadherin-Mediated Cell Repulsion Controls the Central Topography and Efferent Projections of the Abducens Nucleus

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Fig. S6

Ectopic expression of the truncated Pcdh17 proteins in the abducens and spinal motor neurons. (Related to Figure 6)

(A) UAS constructs for expression of the full-length and truncated Pcdh17 proteins. (B) Normal (left), misguided (middle, yellow arrows) and defasciculated (right, white arrows) axon projections of mnr2b-ABNs expressing Pcdh17-FL-mRFP1 at 3 dpf. The bars indicate 50 ?m in left, middle and 20 ?m in right. (C, D) pcdh17-?CPT expression does not affect soma topography and axon projection of mnr2b-ABNs at 3 dpf. Numbers of the nerves investigated are shown in the bar (D). The bars indicate 20 ?m (left) and 50 ?m (right). R, rostral; LL, left lateral, D, dorsal. (E) pcdh17-?CP expression causes clumping of somas and axon projection of spinal motor neurons at 3 dpf. The dashed lines indicate the ventral limit of the spinal cord. The bar indicates 100 ?m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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