FIGURE

Fig. 4

ID

ZDB-FIG-180823-39

Publication

Ma et al., 2018 - Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model

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Fig. 4

Subcellular localization of Danio rerio DDX41 (DrDDX41) and identification of the nuclear localization signal motifs within it. (A) Schematic diagram of full-length (FL) and DrDDX41 mutants with the coiled-coil (CC), DEADc, HELICc, ZnF_C2HC domains, and residue numbers as indicated. The various DrDDX41 fragments were inserted into the C-terminus of pEGFP-N1. (B) Representative images of transfected HEK293T cells. The N-terminal 190 amino acids targeted GFP to the nucleus (a,b). Deletion of this region in DrDDX41 (191–613, c) and DrDDX41 (191–411, d) resulting in punctate cytoplasmic staining and exclusion from the nucleus. Scale bars represent 5 µm. Images were captured under a laser-scanning confocal microscope (Zeiss LSM-710; original magnification, 630×).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol