FIGURE

Fig. 1

ID

ZDB-FIG-180703-4

Publication

Scahill et al., 2017 - The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish.

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Fig. 1

tert^{sa6541/sa6541} fish age prematurely.

(A) Protein domain structure of zebrafish Tert. Depicted in yellow is the telomerase ribonucleoprotein complex RNA-binding domain (RBD), and in purple the reverse transcriptase domain (RTD). The position of three known alleles are shown. (B) tert^{sa6541/sa6541} fish age prematurely. Homozygous fish display a wasting phenotype. Scale bar: 10mm. (C) tert^{sa6541/sa6541} fish die prematurely compared to their siblings (n=92 homozygotes, n=92 heterozygotes, n=92 wild-types). (D) Photograph of capillaries containing sperm from wild-type sibling males (left) and clear fluid containing no sperm from tert^{sa6541/sa6541} males (right). (E) Homozygous tert^sa6541 fish become prematurely infertile. All wild-type males but only 5.9% of homozygous males tested, aged 9 or 10 months, produced sperm. (F) Maternal-zygotic mutant embryos derived from tert^{sa6541/sa6541} intercrosses display a range of phenotypes by 24 h.p.f. including a reduction in head tissue and a shorter tail

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tert^{sa6541/sa6541} tert^{sa6541/sa6541}
Observed In:	caudal fin chromosome, telomeric region head male organism sex determination sperm trunk whole organism
Stage Range:	Prim-5 to Adult

Phenotype Detail

Acknowledgments

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