FIGURE

Fig. 5

ID

ZDB-FIG-180629-7

Publication

Morrice et al., 2018 - Modeling Environmentally-Induced Motor Neuron Degeneration in Zebrafish

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Fig. 5

BPA exposure causes increased motor cell death at 72 hpf. (a) Motor neuron cell death is increased in the spinal cord starting at 72 hpf following BPA exposure as compared to vehicle controls. Values indicate colocalization coefficients between cells with a positive signal for both mnx1-GFP and PI in the spinal cord, indicating dead motor neurons. Group values between time points should be interpreted independently due to non-uniform PI staining between time points. (b) BPA-exposed embryos show colocalization between PI + cells and mnx1 motor neuron soma 96 hpf, and show that PI staining is not specific to mnx1 motor neuron soma. Data represent the mean ± s.d.; N = 7–12 biological replicates. P values were determined by Mann-Whitney U test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hdb2Tg; ml2Tg
Condition:	chemical treatment by environment: bisphenol A
Observed In:	motor neuron cell death
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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