FIGURE

Fig. 9

ID

ZDB-FIG-180620-41

Publication

Leacock et al., 2018 - Structure/Function Studies of the ?4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses

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Fig. 9

Embryos injected with ?4a-SMO1 and the ?4a^R278Q mutant embryos fail to exhibit correct escape behavior. (A) Wild-type (control) fish responds to touch by with a C-bend, a turn away from the stimulus and rapid swimming. However, embryos injected with ?4a-SMO1 (B) or with mRNA for the GlyR ?4a^R278Q subunit (C) respond more slowly, and have a pronounced head retraction?similar to a localized beo-like contraction (arrow). Single images were extracted from high-speed movies of ?4a-SMO1 morphants and embryos injected with GlyR ?4a^R278Q subunit mRNA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-glra4a
Knockdown Reagent:	MO3-glra4a
Observed In:	startle response thigmotaxis
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.